What Type Of Antibiotic Is Chloramphenicol?

What does chloramphenicol do to bacteria?

Chloramphenicol is bacteriostatic but may be bactericidal in high concentrations or when used against highly susceptible organisms.

Chloramphenicol stops bacterial growth by binding to the bacterial ribosome (blocking peptidyl transferase) and inhibiting protein synthesis..

What is the indication of chloramphenicol?

Indications for Chloramphenicol Inj: Serious susceptible infections resistant to other antibiotics. Typhoid fever.

Is chloramphenicol a macrolide?

Abstract. Macrolides, lincosamides, tetracyclines and chloramphenicol are structurally unrelated antibiotics which share protein synthesis inhibition as their common mechanism of action.

Why is chloramphenicol considered as reserved antibiotic?

Chloramphenicol is a broad spectrum antibiotic introduced into clinical practice in 1948, but which was subsequently shown to cause serious and fatal aplastic anemia and is now used rarely and reserved for severe, life-threatening infections for which other antibiotics are not available.

What infections does chloramphenicol treat?

Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. This includes use as an eye ointment to treat conjunctivitis. By mouth or by injection into a vein, it is used to treat meningitis, plague, cholera, and typhoid fever.

Why is chloramphenicol toxic to humans?

Its mechanism of action is by inhibition of bacterial protein synthesis by binding with ribosomes. The major toxicity of chloramphenicol is hematological. In all vertebrates studied, it produces direct, dose-dependent bone marrow depression resulting in reductions in red blood cells, white blood cells, and platelets.

What is the best antibiotic for eye infection?

Patients with symptoms should be referred immediately to an ophthalmologist. Oral antibiotics such as azithromycin or doxycycline are effective treatments.

Is chloramphenicol contraindicated in?

Chloramphenicol is contraindicated in individuals with a history of previous hypersensitivity and/or toxic reaction to it. It must not be used in the treatment of trivial infections or where it is not indicated, as in colds, influenza, infections of the throat.

Why is chloramphenicol banned?

The Committee concluded that the compound is genotoxic, which means it could cause genetic damages and possibly lead to cancer. Chloramphenicol is also known to cause an extremely serious disease in people called “aplastic anemia”.

What is the other name for chloramphenicol?

BRAND NAME: Chloromycetin, Econochlor, Ocu-Chlor (These are discontinued brands in the US) DRUG CLASS AND MECHANISM: Chloramphenicol is a man-made antibiotic.

Is chloramphenicol An antibiotic drug?

Chloramphenicol is an antibiotic. It’s mainly used to treat eye infections (such as conjunctivitis) and sometimes ear infections. Chloramphenicol comes as eye drops or eye ointment. These are available on prescription or to buy from pharmacies.

What happens if you touch chloramphenicol?

PRECAUTION FOR HUMANS: Chloramphenicol can cause permanent damage to the bone marrow in about 1 in 10,000 people. For these people, even skin contact can cause permanent damage.

Is chloramphenicol a steroid?

GENERIC NAME: CHLORAMPHENICOL/HYDROCORTISONE – EYE-EAR OINTMENT (klor-am-FEN-eh-coal/hi-dro-KOR-tih-sown) USES: This medication contains an antibiotic that helps prevent or treat an infection and a steroid which reduces inflammation. It is used in the treatment of various eye (ophthalmic) or ear (otic) conditions.

What type of bacteria does chloramphenicol kill?

It has a role as an antimicrobial agent, an antibacterial drug, a protein synthesis inhibitor, an Escherichia coli metabolite and a Mycoplasma genitalium metabolite.

What is the effect of chloramphenicol?

The most serious adverse effect of chloramphenicol is bone marrow depression. Serious and fatal blood dyscrasias (aplastic anemia, hypoplastic anemia, thrombocytopenia, and granulocytopenia) are known to occur after the administration of chloramphenicol.